tag:blogger.com,1999:blog-6886680068187530519.post2230170917906974460..comments2024-02-07T23:25:07.429-06:00Comments on Bell Beaker Blogger: Origin and Spread of Cystic Fibrosisbellbeakerbloggerhttp://www.blogger.com/profile/01848982163843593127noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-6886680068187530519.post-19197125180884438102015-04-20T12:55:20.024-05:002015-04-20T12:55:20.024-05:00I've been out all weekend. ThanksI've been out all weekend. Thanksbellbeakerbloggerhttps://www.blogger.com/profile/01848982163843593127noreply@blogger.comtag:blogger.com,1999:blog-6886680068187530519.post-68267276356170325852015-04-20T12:54:41.916-05:002015-04-20T12:54:41.916-05:00Very interesting. I'll have to read more into...Very interesting. I'll have to read more into this.<br />bellbeakerbloggerhttps://www.blogger.com/profile/01848982163843593127noreply@blogger.comtag:blogger.com,1999:blog-6886680068187530519.post-6863366393608369652015-04-17T21:12:58.122-05:002015-04-17T21:12:58.122-05:00Very interesting, I never heard of the metal poiso...Very interesting, I never heard of the metal poisoning effect before.capra internetensishttps://www.blogger.com/profile/15951755327460295070noreply@blogger.comtag:blogger.com,1999:blog-6886680068187530519.post-62892398140685589422015-04-17T13:42:26.404-05:002015-04-17T13:42:26.404-05:00Excellent insight with obvious applications to his...Excellent insight with obvious applications to historical population genetics and the Bell Beaker people in particular.andrewhttps://www.blogger.com/profile/08172964121659914379noreply@blogger.comtag:blogger.com,1999:blog-6886680068187530519.post-76091554726956133612015-04-17T09:03:42.450-05:002015-04-17T09:03:42.450-05:00Excellent post, cheers!
Also, I wonder if livesto...Excellent post, cheers!<br /><br />Also, I wonder if livestock domestication led to an increase in CF transmission among genetically susceptible populations.<br /><br />http://www.bbsrc.ac.uk/documents/amr-making-the-leap-pdf/<br /><br />Making the leap: Cross-species transmission of Staphylococcus aureus<br />"Research led by Professor Ross Fitzgerald from the Roslin Institute at the University of Edinburgh, and others, has found that S. aureus has made numerous leaps between host species; from humans to animals such as dairy cattle and pigs and vice versa. In particular, a 2013 study by Professor Fitzgerald and colleagues showed that a bovine strain called CC97 had made two separate leaps to humans. “There may be a lot more cross-species transmission than we anticipated,” says Professor Fitzgerald. "<br /><br />It seems that the most common HLA haplotype among Europeans, which reaches peak world frequency in the Irish, might have been selected for as it appears to delay the onset of colonization in CF.<br /><br />http://intimm.oxfordjournals.org/content/18/11/1585.full.pdf<br /><br />The 8.1 ancestral MHC haplotype is associated with delayed onset of colonization in cystic fibrosis<br />Abstract<br />"Major cause of death in patients with cystic fibrosis (CF) is colonization with Staphylococcus aureus and Pseudomonas aeruginosa. The wide phenotypic variation in CF patients suggests that genes other than the cystic fibrosistransmembrane conductance regulator (CFTR) gene modify the disease. The 8.1 ancestral haplotype (8.1AH) in main histocompatibility complex is associated with alterations of the immune response. To study the influence of carriage of 8.1AH on frequency and onset of colonization in CF patients, DNA samples of 72 CF patients (39 homozygous and 33 heterozygous for DF508) were genotyped for member alleles of the 8.1AH: HLA-DQB1*0201, HLA-DRB1*0301, receptor for advanced glycation end products (AGER) 429C, HSP70-2 1267G (HSP70-2G) and tumor necrosis factor-a (TNF-a) 308A (TNF2). Colonization was verified by regular clinical and bacteriological screening. Frequency of colonization was significantly (P=0.012) lower in the 8.1AH carriers; age, gender and DF508 genotype-adjusted odds ratio to be colonized of the carriers versus non-carriers was 0.112 (0.024–0.520). According to survival analysis, patients with 8.1AH had significantly (P<0.0001) longer colonization-free period compared with non-carriers. Our novel observations demonstrate that the 8.1AH is associated with delayed onset of colonization in CF, presumably by influencing defense mechanisms against infections"<br /><br />http://en.wikipedia.org/wiki/HLA_A1-B8_haplotype<br />http://en.wikipedia.org/wiki/HLA_A1-B8-DR3-DQ2<br />https://en.wikiversity.org/wiki/HLA/A*01:01:01:01<br />https://en.wikiversity.org/wiki/HLA/B*08:01:01<br />https://en.wikiversity.org/wiki/HLA/DRB1*03:01:01:01<br />Anonymoushttps://www.blogger.com/profile/13013399855770625556noreply@blogger.comtag:blogger.com,1999:blog-6886680068187530519.post-88392574943903965852015-04-16T18:56:24.860-05:002015-04-16T18:56:24.860-05:00I may not be able to respond to comments very quic...I may not be able to respond to comments very quickly. FYIbellbeakerbloggerhttps://www.blogger.com/profile/01848982163843593127noreply@blogger.com